Figure 3

Effect of infliximab on circulating IL-1ra in patients treated with a single infusion of infliximab or placebo on Day 0. Infliximab 1 mg/kg (closed triangle ▲), infliximab 10 mg/kg (closed square ■), and placebo (open circle ○). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 compared with placebo. Adapted with permission from Charles et al. [19]. Copyright 1999. The American Association of Immunologists.