Fig. 4

Rate of resolution of swollen joints (HR and 95% CI) after start of TNFi with additional adjustment for patient profiles with different joint involvement clusters in comparison to Fig. 3. The rate of resolution of synovitis for different comparisons (A, B, C) is estimated using overall interval-censored mixed-effects Cox proportional hazards models: A joints along the proximal–distal axis of the upper limb, B finger joints along the anterior–posterior axis of the hand (digits 1–5), C knee compared to elbow. The reference joint(s) are indicated in each panel. The numbers of swollen joints and of patients are shown for each joint location. MCP3 = metacarpophalangeal joint of digit 3; PIP3 = proximal interphalangeal joint of digit 3