Table 2 Serum cytokine levels stratified by IA severity. Median [IQR] cytokine levels per CDAI category for all patients. Krushkal Wallis test was performed to determine statitstical significance
Cytokine (pg/ml) | Low (n = 21) | Moderate (n = 35) | High (n = 20) | p-value* |
|---|---|---|---|---|
IFNγ | 23.4 [15.4, 67.8] | 26.0 [10.2, 87.3] | 33.4 [18.1, 85.0] | 0.71 |
IL-1 | 0 [0, 1.5] | 0 [0, 0.72] | 0 [0, 0] | 0.83 |
IL-4 | 0 [0, 0] | 0 [0, 0.04] | 0 [0, 0] | 0.67 |
IL-6 | 9.6 [2.0, 22.4] | 12.1 [4.2, 56.0] | 58.4 [2.9, 100.2] | 0.21 |
IL-10 | 3.0 [2.3, 3.5] | 2.0 [1.2, 3.1] | 3.0 [1.6, 5.0] | 0.18 |
IL-12p70 | 0 [0, 0.10] | 0 [0,0] | 0 [0, 0] | 0.67 |
IL-17 A | 0 [0, 0] | 0 [0, 3.6] | 0 [0,0] | 0.31 |
TNFα | 7.1 [4.3, 9.3] | 6.8 [5.1, 8.7] | 8.9 [5.6, 13.3] | 0.20 |
VEGF-A | 791 [394, 1240] | 1439 [817, 2002] | 987 [476, 2946] | 0.02 |