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Table 4 Baseline cytokine levels stratified by TNF-I response. Comparison of baseline cytokine levels median [IQR] for those with and without arthritis response to TNF-inhibitor therapy. Mann-Whitney test was performed to determine statistical significance

From: Higher levels of VEGF-A and TNFα in patients with immune checkpoint inhibitor-induced inflammatory arthritis

Cytokine

(pg/ml)

TNF-I response

(n = 11)

No response

(n = 5)

p-value*

IL-6

53.1

[3.2, 90.8]

2.1

[1.7, 2.1]

0.03

TNFα

8.0

[6.0, 12.5]

5.1

[4.3, 5.1]

0.02

VEGF-A

2246

[723, 5077]

1552

[1108,1958]

0.58