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Table 3 Top 25 differentially expressed genesets in ACPA- IA vs. HCs

From: Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients

GeneSet

Number of Genes in GeneSet

Direction

P Value

False Discovery Rate

C2_REACTOME_RESPIRATORY_ELECTRON_TRANSPORT

61

Down

< 0.0001

< 0.0001

C2_KEGG_LYSOSOME

110

Up

< 0.0001

< 0.0001

C2_REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP SYNTHESIS_BY CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_

UNCOUPLING_PROTEINS_

77

Down

< 0.0001

< 0.0001

C2_REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY THE_43S_COMPLEX

47

Down

< 0.0001

0.0004

C2_REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

111

Down

< 0.0001

0.0015

C2_REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_

AND_REPLICATION

97

Down

< 0.0001

0.0020

C2_REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_

REGULATION

104

Down

< 0.0001

0.0021

C2_KEGG_RIBOSOME

87

Down

< 0.0001

0.0025

C2_REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_

SUBSEQUENT_BINDING_TO_43S

55

Down

< 0.0001

0.0025

C2_REACTOME_PEPTIDE_CHAIN_ELONGATION

85

Down

< 0.0001

0.0028

C2_KEGG_PARKINSONS_DISEASE

103

Down

< 0.0001

0.0033

C2_KEGG_OXIDATIVE_PHOSPHORYLATION

109

Down

< 0.0001

0.0090

C2_REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION

75

Up

0.0001

0.0101

H_HALLMARK_OXIDATIVE_PHOSPHORYLATION

191

Down

0.0001

0.0101

C2_REACTOME_INFLUENZA_LIFE_CYCLE

130

Down

0.0002

0.0118

C2_REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_

CALNEXIN_CALRETICULIN CYCLE

12

Up

0.0003

0.0218

C2_KEGG_HUNTINGTONS_DISEASE

157

Down

0.0006

0.0370

C2_REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_

BY_THE_EXON_JUNCTION_COMPLEX

106

Down

0.0006

0.0370

C2_KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_

PRODUCTION

43

Up

0.0015

0.0878

C2_REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_

WITH_MYCOBACTERIUM_TUBERCULOSIS

28

Up

0.0016

0.0878

C2_REACTOME_METABOLISM_OF_MRNA

208

Down

0.0019

0.0900

C2_REACTOME_TRIGLYCERIDE_BIOSYNTHESIS

38

Down

0.0019

0.0900

C2_KEGG_LEISHMANIA_INFECTION

60

Up

0.0019

0.0900

C2_KEGG_N_GLYCAN_BIOSYNTHESIS

43

Up

0.0019

0.0900

C2_KEGG_ALZHEIMERS_DISEASE

147

Down

0.0022

0.1010

  1. Table outlining the top 25 differentially expressed genesets in ACPA- inflammatory arthritis compared to healthy controls following geneset enrichment analysis (GSEA), focusing on HALLMARK, BIOCARTA, KEGG and REACTOME genesets
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Arthritis Research & Therapy

ISSN: 1478-6362

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